Společnost pro kognitivní vědu a filosofii Vás srdečně zve na červnovou přednášku, kde vystoupí autor adaptivní hypotézy deprese Paul Andrews s tématem The evolution of depressive phenotypes. Přijďte si ho poslechnout ve čtvrtek 9. 6. 2016 o 18:00 na FF UK, Náměstí Jana Palacha (místnost P018).

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Abstrakt

There is concern that current diagnostic criteria for depression do not accurately distinguish between normal, adaptive responses to stress and disordered brain states. Moreover, depression is not a unitary entity. It is a heterogeneous collection of phenotypes sharing partially overlapping genes, neurobiology, and symptoms. I examine three reliably diagnosed depressive phenotypes to ascertain their evolutionary history and functional significance: (1) sickness behavior; (2) starvation depression; and (3) melancholia. This comparison suggests that depressive symptoms evolved in response to persistent stressors (infection, starvation) that require the body to make a sustained reallocation in limited energetic resources. These phenotypes, although distinct, are functionally similar, which explains the overlapping genetics and symptomatology. Specifically, depressive symptoms are part of a coordinated response in which metabolic processes associated with growth and reproduction are suppressed because they would otherwise draw energy away from the stress response. Sickness behavior and starvation depression evolved early on the phylogenetic tree of life and show adaptation for reallocating energy towards promoting immune function and maintenance, respectively. Melancholia evolved more recently and shows signs of adaptation for analyzing complex problems, and probably evolved as an adaptive response to problems involving scarce resources or conflicts with close social partners. This talk will focus on melancholia, but implications for understanding specific depressive phenotypes in various medical conditions (anorexia nervosa, Alzheimer’s disease, schizophrenia, and diabetes) will be discussed.